The Pet Central ProjectPain Relief Medication for Dogs

A week hasn't gone by since we had Dr. Stephen Jaffe on "Pet Central" that we haven't received a least one email or note in the mail about pain relief. Jaffe introduced what was then an all new product called EtoGesic Tablets. "Pet Central" was the first to report on this new product in the Chicago area.

EtoGesic is a safer than aspirin alternative pain killer for dogs, manufactured by Fort Dodge Animal Health. Thanks to products like EtoGesic vets no longer tell their canine clientele, "Take two aspirin and call me in the morning." Aspirin and steroids were once the pain killers of choice to ease the formidable pain created by hip and/or elbow dysplasia, and osteoarthritis, but long-term usage caused problems including butchering gastro intestinal systems.

In 1997, Rimadyl came to the rescue as the first in a line of alternatives to alleviate pain associated with osteoarthritis. Within a year Adequan Canine and Cosequin became available, and now there's EtoGesic. While all these products offer pain relief, they all work differently; consumers can easily become confused about which is best for their specific situation. Naturally, you have to consult your vet about that. But it never hurts to understand what they're all about. For one thing, none of these products will cure osteoarthritis or dysplasia; they're about helping dogs to feel better.

The good news is that the products do work for many pets, in some cases, may even work miracles. Hundreds - who knows, maybe even in excess of a thousand dogs - who otherwise might have been euthanized as the only relief for crippling chronic pain - now have a new lease on life. You can't emphasize that statement enough.

On "Pet Central," we pointed out the new pain relievers have revolutionized veterinary medicine. Still, much remains unclear about their effectiveness including potential long-term side-effects, and under what circumstances which pets are most likely to benefit. On some dogs some of these products may have little or no effect. And none of these medications come cheap.

The following is a basic guide to the most popular of these products for dogs. with guidance from Dr. Steven Budsberg a leading authority on pain relievers and Board Certified Orthopedist and professor of surgery at the University of Georgia College of Veterinary Medicine - Athens, and Dr. Claude Gendreau, a American Veterinary Medical Association Board Certified Orthopedist from Riverwoods. Neither of these two distinguished vets is associated with any of the pain relief products.

Adequan Canine: Unlike drugs which only treat the symptoms of arthritis, Adequan Canine claims to alter the destructive cycle of the disease itself. It's unclear exactly at what extent the product is able to do this, but it seems to only be able to slow down the progression of early osteoarthritis. Presumably Adequan offers ingredients to assist cartilage to re-build after breakdown, and inactivates "bad" enzymes that destroy cartilage.

However, when the disease has fully progressed, the drug may be less effective. For this reason, current thinking is that younger dogs who haven't fully developed the disease are the best candidates for Adequan.

Adequan is an injectable to be administered twice weekly for four weeks. The good news and bad news is that clients must have the product given as a "shot" by their vet. This is one certain means the vet can regularly observe the dog. However, in the real world, visiting a vet twice weekly may not be convenient, or even an option. There are no known side-effects to Adequan Canine.

Cosequin: This is a nutraceutical, falling somewhere between a pharmaceutical and nutritional supplement. It is the only product listed here that is not FDA approved, and it is the most controversial of the pack. Some vets refuse to prescribe Cosequin pills, calling it a waste of money; other vets do consider this a serious alternative for pain relief and have witnessed amazing results.

The primary ingredients in Cosequin are Glucosamine/Chondroitin Sulfate. People with arthritis also use Glucosamine, which can be found at health food stores, and the results vary among people too.

The theory goes something like this: Cosequin provides building blocks for cartilage. Current thinking for those who believe Cosequin can be effective is to put a dog on Cosequin long-term to hopefully slow the degenerative process, while using a non-steroidal anti-inflammatory (Rimadyl or EtoGesic Tablets) as needed when there's a flare-up creating pain.

Bottom line: Hard evidence - meaning scientific documentation - is most suspect for this product. Generally, side-effects have not been reported.

Rimadyl and EtoGesic Tablets: They are two separate drugs, but each has much in common. They are both non-steroidal anti-inflammatories. Both drugs are related to aspirin, but tend to be kinder and gentler to canine tummies. Both these products claim to halt the production of prostra glandin E2, a normally produced substance that creates inflammatory response. By decreasing the inflammation, pain is resolved.

Some dogs do suffer stomach upset with Rimadyl, which is why EtoGesic may be an alternative, or visa versa. "One pill may work for one dog's body and not another dog," says Budsberg. "When it comes to non-steroidal anti- inflammatories, it's good to have choices." Additional choices are soon expected to enter the market. Rimadyl recommends two pills daily, and EtoGesic one tablet daily. In some cases, EtoGesic may be moderately less expensive.

When Rimadyl first entered the scene, it was a hotly debated topic on the internet. It still is. Now, there are entire websights and online chats devoted to claims that Rimadyl is extremely dangerous. Gendreau and Budsberg agree Rimadyl is less dangerous to dogs than aspirin is to people. "The odds of positive results far outweighs any harmful effects," Budsberg says.

Rimadyl may cause serious liver damage or kidney dysfunction in an a minuscule population of dog, and Labrador retrievers appear to be the most affected. As a result, playing it safe legally, Rimadyl's manufacturer (Pfizer Animal Health) now recommends periodic liver enzyme tests for Labs on the drug. However, Budsberg says there's an inherent potential danger with any drug and isn't concerned about Rimadyl's safety; he admits there's still a great deal to be learned about long-term usage of any of these medications. Concerning similar side effect in EtoGesic, Budsberg says it's too new on the market, too early to tell.

Rimadyl or EtoGesic are the drugs of choice to ease pain related to a canine sports injury.

   

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